Cisplatin cystenyl glycine conjugate

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August undefined, 2024

http://nopr.niscair.res.in/bitstream/123456789/12869/1/IJEB%2049(10)%20791-794.pdf WebThis enzyme uses cysteine conjugates as substrates, releasing the thiol derivative of the original xenobiotic, ammonia, and pyruvic acid, the thiol derivative then undergoing S-methylation to give rise to the methylthio derivative.

Cysteine Conjugate - an overview ScienceDirect Topics

WebJan 24, 2024 · GSTs are able to conjugate glutathione (γ- l -glutamyl- l -cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs,... WebNov 1, 2001 · The cysteine-conjugates are taken up into the cell and converted to a reactive thiol by either cysteine-conjugate β-lyase or S-oxidase. ... cisplatin-cysteinyl-glycine-conjugates, and cisplatin-cysteine-conjugates are all more toxic to proximal tubule cells than cisplatin. 25 We have also shown that inhibition of cysteine-conjugate β-lyase by ... ioof expand term deposits

Inhibition of γ-Glutamyl Transpeptidase or Cysteine S …

WebJan 1, 2024 · As the cisplatin-GSH-conjugate passes through the kidney, it is cleaved by GGT to a cysteinyl-glycine-conjugate, which is further converted to a cysteine … WebSep 15, 2024 · Cisplatin forms a Pt-GSH-conjugate in the liver and then reaches the kidneys, which is cleaved by GGT produces cysteinyl-glycine-conjugate, followed by the production of a cysteine-conjugate by aminopeptidases on the … WebFeb 16, 2024 · Cisplatin Pregnancy Warnings. Use is contraindicated. US FDA pregnancy category: Not assigned. `Risk Summary: Based on human data, this drug can cause fetal … on the lot meaning

Sodium selenite attenuated cisplatin-induced toxicity in rats: …

Glutathione transferases: substrates, inihibitors and pro-drugs …

WebCisplatin (24 mg/kg body weight) was given by a single intraperitoneal injection. Mice were killed at day 1 or day 3 after cisplatin administration, blood and kidney samples were harvested for further analysis. Renal ischemia-reperfusion was induced in mice as described previously [ 21, 22 ]. WebFeb 1, 2003 · Cisplatin-cysteine conjugates are suggested to be reabsorbed via renal cysteine heterodimeric amino acid transporters such as system-L, system-b0,+ or system … ioof exit feesWebAug 1, 2007 · Cisplatin/cysteinyl-glycine complexes were also found in the supernatant of GGT-transfected cisplatin-resistant HeLa cells ; this finding seems to indicate a poor membrane permeability of thiol/cisplatin complexes. It shouldalso be considered that cysteinyl-glycine reacts with cisplatin, approximately fivefold faster than GSH . ioof event center corsicana

"WebMei Deng is a academic researcher from University of Virginia. The author has contributed to research in topic(s): Nephrotoxicity & Conjugate. The author has an hindex of 3, co-authored 3 publication(s) receiving 322 citation(s). Previous affiliations of Mei Deng include Veterans Health Administration. " - Cisplatin cystenyl glycine conjugate

Cisplatin cystenyl glycine conjugate

Signalling mechanisms involved in renal pathological changes

WebSep 8, 2024 · Cisplatin Glutathione conjugated cisplatin can be metabolized to a cysteinyl-glycine-conjugate, to a cysteine conjugate, and finally to a reactive thiol that is highly nephrotoxic . Alternatively, it is thought that glutathione conjugation, mediated by GSTA1, is a detoxification pathway responsible for cisplatin resistance in solid tumors ... WebCysteinylglycine C5H10N2O3S - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National …

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WebNational Center for Biotechnology Information WebIn brief, cisplatin enters the cell by both active transport and passive diffusion; however, transport- mediated uptake is the major intake mechanism in renal cells [3]. Two …

WebMar 1, 2009 · In a series of papers, Hanigan and coauthors reported that the Pt-cysteine S-conjugate was converted to a toxic, highly reactive Pt-thiol by any of the several … Webwww.ncbi.nlm.nih.gov

WebMetabolism of glutathione conjugate and the cystenyl-glycine conjugate occurs extracellularly, the cysteine conjugate metabolized intracellularly to reactive thiol by cysteine-S conjugate-lyase. The osmotic stress response could be affecting any of several steps in this pathway2, thus help to reverse the toxic effect of Cisplatin. WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …

WebThe first step is the conjugation to glutathione, followed by the cleavage by GGT to a cysteinyl-glycine conjugate, the cleavage by aminopeptidase to a cysteine S …

WebMay 1, 2003 · Cisplatin cytotoxicity was judged by its antiproliferative action. Incubations with GSH were performed in the presence and in the absence of the dipeptide GlyGly (20 mM), added as an acceptor for the transpeptidation reaction [15] to replace the physiological acceptor cystine [18]. ioof expand contactWebJun 1, 2003 · Search worldwide, life-sciences literature Search. Advanced Search E.g. "breast cancer" HER2 Smith J ... on the lot 意味WebStudies of placental DNA adducts have mainly focused on PAH-compounds (e.g. BP and its derivates) or AFB1, because they are metabolized by CYP1A1 found in human placenta. It remains to be studied whether any of the substrates of other CYP enzymes are metabolized in human placenta to reactive metabolites which form DNA adducts. on the lot star worldWebCisplatin is a potent antitumor agent currently used in the treatment of germ cell tumors, head and neck tumors, cervical cancer, and as a salvage treatment for other solid tumors … on the lot showWebAug 28, 2009 · This glutathione–cisplatin conjugate is further metabolized by the enzymes gamma-glutamyl transpeptidase (GGT) or aminopeptidase N (APN), and cysteine-S … ioof essentials ddoWebJan 30, 2024 · Cisplatin (CP) is a broad-spectrum antineoplastic agent, used to treat many different types of malignancies due to its high efficacy and low cost. ... The resulting GSH-conjugates are cleaved into a cysteinyl-glycine-conjugate by gamma glutamyltranspeptidase which is localized on the surface of the kidney proximal tubule … ioof expand essentil superWebJan 1, 2003 · Europe PMC is an archive of life sciences journal literature. Please help EMBL-EBI keep the data flowing to the scientific community! Take part in our Impact Survey (15 minutes). ioof expand forms