Cisplatin coordination complex

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August undefined, 2024

Webcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells. cis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells ... Cisplatin / metabolism Cisplatin / pharmacology* Cisplatin / therapeutic use Combined Modality Therapy DNA Replication … WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of …

Platinum Coordination Complexes - PubMed

WebPlatinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. Their active moieties are coordination complexes of platinum. These drugs are used to treat almost half of people receiving chemotherapy for cancer. WebStimulated by the enormous success of the inorganic complex cisplatin in tumor treatment, interest in metal complexes has recently grown. Within cells, metal complexes can participate in reactions that are not possible with conventional organic substances, and most of them have promising efficacy as anticancer drugs. inclusion\\u0027s 6k

Platinum metal complexes in medicine - Chemistry World

WebStructure of cisplatin, an example of a molecule with the square planar coordination geometry. The square planar molecular geometry in chemistry describes the stereochemistry (spatial arrangement of atoms) that is adopted by certain chemical compounds. As the name suggests, molecules of this geometry have their atoms … WebJul 19, 2024 · Cisplatin and drug design 16–18 years Resource RSC Education Assess learners’ understanding of the mechanism of cisplatin as an anticancer drug with these examination-style questions. WebSep 12, 2024 · The platinum coordination complexes are a group of antineoplastic agents that are usually classified as alkylating agents, but which have distinctive features. Their anticancer activity appears to relate to the cross linking of DNA molecules in a fashion similar to standard alkylating agents. incarnate powers city of heroes

Investigation of the Anticancer Activity of Coordination-Driven …

Supramolecular Delivery Systems for Non-Platinum Metal …

WebMontgomery County, Kansas. Date Established: February 26, 1867. Date Organized: Location: County Seat: Independence. Origin of Name: In honor of Gen. Richard Montgomery (1738-1775), a Revolutionary War hero who led the army into Canada, capturing the city of Montreal; he died while attempting to capture Quebec. WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, … inclusion\\u0027s 6mWebSep 12, 2024 · The platinum coordination complexes are a group of antineoplastic agents that are usually classified as alkylating … incarnate root

"WebMethods: The contribution of aliphatic acyclic, aliphatic cyclic, and aromatic diamine ligands to the anticancer activity and selectivity/toxicity of metal complexes with different metal ions were analyzed by comparison with organic ligand alone and/or conventional platinum-based chemotherapeutics. " - Cisplatin coordination complex

Cisplatin coordination complex

Cisplatin (Cisplatin Injection): Uses, Dosage, Side Effects ... - RxList

WebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity … Cisplatin: The first metal based anticancer drug WebMar 29, 2024 · Reviewed on 3/29/2024. Cisplatin: An anticancer drug that belongs to the family of drugs called platinum compounds. Cisplatin is used in the treatment of a wide …

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WebJul 4, 2024 · Coordination numbers of two and three are common for d 10 metal ions. Tetrahedral and square planar complexes have a coordination number of four; trigonal … WebCancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers globally to find alternative treatment options is ongoing. In the …

WebMay 10, 2024 · Notable examples include the anticancer drugs cisplatin ( PtCl 2 ( NH 3) 2 ). A square planar complex also has a coordination number of 4. The structure of the complex differs from tetrahedral because the ligands form a simple square on the x and y axes. Because of this, the crystal field splitting is also different (Figure 1 ). WebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. …

Webazane;dichloroplatinum Cl2H6N2Pt CID 5702198 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... WebMar 20, 2024 · Till today, cisplatin, carboplatin, and oxaliplatin are still extensively applied in the treatment of cancer. Cisplatin ( Figure 1) is a neutral, square planar coordination complex of platinum (II) coordinated to two chloride and two ammonia groups, where the chloride ligands are in the cis-geometry ( Kartalou and Essigmann, 2001 ).

WebThe platinum coordination complex cisplatin, or cis -diamminedichloroplatinum (II) (see Figure 1 ), functions as a cytotoxic anticancer chemotherapy agent and shows a remarkable degree of selectivity in destroying testicular cancer cells.

WebSep 18, 2024 · National Center for Biotechnology Information incarnate robe ornaWebCisplatin coordinates to DNA mainly through certain nitrogen atoms of the DNA base pairs; these nitrogen atoms (specifically, the N7 atoms of purines) are free to … inclusion\\u0027s 6tWebFeb 28, 2024 · It was discovered that both iodide complexes, 9a and 9b, were more effective than the chloride analogs, 10a and 10b, and cisplatin against all cisplatin-resistant cell lines; while the chloride complexes had an effect comparable to cisplatin: 11 and 11.9 μM vs. 4 μM in the A2780 cell line; 21 and 19 μM vs. 22 μM in the A2780cisR … inclusion\\u0027s 6pWebCisplatin contains a central Pt ion with four ligands. The two chloride ligands can undergo ligand substitution to allow cisplatin to bind to a guanine base on DNA. This property is … inclusion\\u0027s 6rWebSep 5, 2015 · Taken together, the complex has been shown to be a potential DNA damaging agent and, in the light of the superiority of the complex over cisplatin, we are further investigating the possibility of targeted nano-delivery of … inclusion\\u0027s 6oWebCisplatin Cl2H6N2Pt CID 5460033 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity … inclusion\\u0027s 6zWebcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells cis-Diamminedichloroplatinum(II): effects of a representative metal … incarnate root word