WebSNAIL1 ELISA Kits. Ready-to-use ELISA kits are available for the detection of SNAIL1, an alias of the protein, snail family transcriptional repressor 1. The official gene symbol is … WebJan 14, 2024 · SNAIL1 is an unstable transcription factor that is phosphorylated by GSK3-beta ( 605004) in the nucleus, which triggers its nuclear export and subsequent ubiquitination and proteasomal degradation. Using human and mouse cell lines, Vinas-Castells et al. (2010) found that FBXL14 ( 609081) also directed ubiquitination and …
Snail genes as inducers of cell movement and survival: …
WebDescription: The monoclonal antibody 20C8 recognizes human Snail1, a 29 kDa zinc finger transcription factor. Snail1 and Slug both belong to a family of transcription factors that are responsible for inducing epithelial to … WebDec 8, 2024 · CDK4/CDK6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. Study examined proliferation rates of cortical progenitor cells in mice lacking individual cdk proteins or combinations thereof. Results provide evidence that concomitant loss of cdk4 and cdk6 leads to reduced proliferation rates specifically in … field service dispatch
Entry - *604238 - SNAIL FAMILY TRANSCRIPTIONAL REPRESSOR 1; SNAI1 …
WebJun 22, 2012 · Snail1 proteins have a highly conserved β-catenin-like consensus motif and destruction box. GSK-3β phosphorylates motif 2 of Snail1 and thereby induces its nuclear export, whereas subsequent phosphorylation by GSK-3β at motif 1 results in the association of Snail1 with β-TrCP and thus leads to the degradation of Snail1 . It is thus ... WebJan 9, 2024 · Mechanistically, we identify a deubiquitinase, DUB3, as a target of CDK4/6; CDK4/6-mediated activation of DUB3 is essential to deubiquitinate and stabilize SNAIL1, a key factor promoting ... WebNov 1, 2014 · SNAIL1 has been suggested to regulate breast cancer metastasis based on analyses of human breast tumor transcriptomes and experiments using cancer cell lines and xenografts. However, in vivo genetic experimental support for a role for SNAIL1 in breast cancer metastasis that develops in an immunocomp … field service demo